Structural aspects of glycomes with a focus on N-glycosylation and glycoprotein folding |
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| Authors: | Petrescu Andrei-José Wormald Mark R Dwek Raymond A |
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| Institution: | 1. School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor, Gwynedd LL57 2UW, UK;2. Institute of Marine Research, PO Box 1870, Nordness, 5870, Bergen, Norway;1. School of Laboratory Medicine, Hangzhou Medical College, Hangzhou, China;2. Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China;3. Department of Biology, Chemistry, Pharmacy, Free University of Berlin, Berlin 14195, Germany;4. Department of Anesthesiology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China;5. Shenzhen Key Laboratory of Genitourinary Tumor, Department of Urology, Shenzhen Second People''s Hospital (Shenzhen Institute of Translational Medicine), The First Affiliated Hospital of Shenzhen University, Shenzhen, China;6. Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People''s Hospital (Shenzhen Institute of Translational Medicine), Shenzhen, China;1. Dept. of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway;2. Dept. of Haematology and Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway;3. Institute of Clinical Medicine, University of Oslo, Oslo, Norway;4. Department of Pathology, Oslo University Hospital, Oslo, Norway;5. Dept. of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway;6. Department of Research, Vestre Viken, Drammen, Norway;7. Department of Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway;8. Department of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway |
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| Abstract: | The pace of data accumulation in glycobiology has lately rapidly increased, largely due to high-throughput technologies. In this increasingly data-rich environment, computer science started to play a central role in handling the data, extracting significant biological information, and probing the missing parts of the 'scenery' by prediction, modelling or simulation. Investigating and comparing glycomes by bioinformatics and structural methods has great practical value and sharply increased in popularity in the past couple of years. In this context, advances have also been made with regard to structural aspects of protein N-glycosylation and consequences for glycoprotein folding. In these areas, however, an approach that integrates glycobiology with protein science is necessary. |
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