Evaluation of new porous β-tri-calcium phosphate ceramic as bone substitute in goat model |
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| Institution: | 1. West Bengal University of Animal and Fishery Sciences, 37 & 68, Kshudiram Bose Sarani, Kolkata 700037, India;2. Central Glass and Ceramic Research Institute, 196, Raja S.C. Mullick Road, P.O.: Jadavpur University, Kolkata 700032, India;1. Department of Surgery, University of California Irvine Medical Center, Orange, California;2. Institute for Clinical and Translational Science, University of California Irvine, Irvine, California;1. School of Resources and Safety Engineering, China University of Mining and Technology, Beijing 100083, China;2. Yuwu Coal Co. Ltd, Shanxi Lu’an Mining Group, Changzhi 046103,China;3. School of Mines, China University of Mining and Technology, Xuzhou 221116, China;4. State Key Laboratory of Coal Resources and Safe Mining, China University of Mining and Technology, Xuzhou 221116, China;1. Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang Normal University, Huanggang 438000, China;2. Key Lab of Mesoscopic Chemistry MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China;1. Faculty of Safety Engineering, China University of Mining & Technology, Xuzhou, Jiangsu, China;2. Lu׳an Mining Group, Changzhi, Shanxi, China;3. Key Laboratory of Gas and Fire Control for Coal Mines, China University of Mining & Technology, Xuzhou, Jiangsu, China;4. Lu׳an Group Gaohe Energy Co. Ltd., Shanxi 047100, China;1. College of Pharmacy, Nankai University, Tianjin 300071, PR China;2. College of Pharmacy and The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China;3. College of Environmental Science and Engineering, Nankai University, Tianjin 300071, PR China;4. Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Tianjin 300071, PR China;5. College of Resources and Environmental Science, Chongqing University, Chongqing 400044, PR China;1. State Key Laboratory of Geomechanics and Deep Underground Engineering, China University of Mining & Technology, Xuzhou 221008, China;2. Civil Engineering and Architecture, Shandong Key Laboratory of Civil Engineering Disaster Prevention & Mitigation, Shandong University of Science and Technology, Qingdao 266590, China |
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| Abstract: | The present study was carried out to evaluate the porous β-tri-calcium phosphate (TCP) (prepared by aqueous solution combustion technique) as bone substitute and compared with normal healing in 12 adult Black Bengal goats on the basis of clinical and radiographic findings, histological studies, oxytetracycline labeling, angiography studies (on day 90). Bone defects created in the diaphysis of radius were left unfilled in control animals (group I); while in treated (group II) animals the defects were filled with porous TCP blocks. The three months study showed no marked acute inflammatory reactions in all animals, wound healing was uneventful and the implants were clinically stable in the bone. Radiological studies showed presence of unabsorbed implants which acted as a scaffold for new bone growth across the defect whereas in control animals the defect was more or less same except that the newly formed bony tissue was less organized. Histological section showed moderately differentiated lamellar bone in the cortical part with presence of woven bone at peripheral cortex whereas control animals showed moderate fibro-collagenisation and good amount of marrow material, fat cells and blood vessels. Oxytetracycline labeling study showed crossing over of new bony trabeculae along with presence of resorption cavities within the new osteoid tissues whereas in group I, the process of new bone formation was active from both the ends; the defect site appeared as a homogenous non-fluorescent area. Angiogram of the animals in control showed uniform angiogenesis in the defect site with establishment of trans transplant angiogenesis, whereas in group II there was complete trans transplant shunting of blood vessels communication. The results of this study pointed out that the porous TCP promoted extensive bone formation over the entire extension of the defect in comparison to control group, thus conforming their biological osteoconductive property. |
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