Efficacy of halofuginone lactate for the treatment and prevention of cryptosporidiosis in goat kids: An extensive field trial |
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| Institution: | 1. Clinic of Farm Animals, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;2. Laboratory of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;3. Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan;1. State Key Laboratory of Refractories and Metallurgy, Department of Materials Science and Engineering, Wuhan University of Science and Technology (WUST), Wuhan 430081, PR China;2. Zhejiang Zili Corporation Limited, Shangyu 312300, PR China;1. Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino (FI), Italy;2. Dipartimento di Farmacia, Università di Pisa, Via Bonanno, 6, 56126 Pisa (PI), Italy;3. Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Via Savi 1, 56126 Pisa (PI), Italy;4. Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna (BO), Italy;1. Department of Solid State Engineering, University of Chemistry and Technology, Prague, Czech Republic;2. Faculty of Science, University of J. E. Purkyně, Ústí nad Labem, Czech Republic;1. Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, v.v.i., České Budějovice, Czech Republic;2. Faculty of Agriculture, University of South Bohemia in České Budějovice, Czech Republic;3. Faculty of Economics, University of South Bohemia in České Budějovice, Czech Republic;4. Veterinary and Microbiological Sciences Department, North Dakota State University, Fargo, USA |
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| Abstract: | The effects of halofuginone lactate (100 μg/kg B.W.) for the treatment and prevention of cryptosporidiosis in goat kids was evaluated in 3 field trials. Trial 1 was to assess the efficacy of halofuginone on the treatment of kid diarrhoea caused by Cryptosporidium spp. Halofuginone given for 7 and for 3 consecutive days, respectively, was effective for the treatment of diarrhoea (P < 0.05). Also, halofuginone administered for a 7-day treatment was significantly (P < 0.05) more effective than a 3-day treatment in reducing the incidence of diarrhoea in the infected goat herds.In the second trial halofuginone given for 7 days reduced significantly (P < 0.05) the diarrhoea incidence, the time of oocyst shedding and the mean intensity of shedding.In the third trial halofuginone was effective in reducing the death rate and preventing cryptosporidiosis. It was concluded, that halofuginone lactate at a dosage rate of 100 μg/kg for 7 days was effective in treatment and prevention of kid cryptosporidiosis. |
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