Characterization of the effect of Melanocortin 1 Receptor,a member of the hair color genetic locus,in alpaca (Lama pacos) fleece color differentiation |
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| Affiliation: | 1. Brigham Young University, Department of Plant and Wildlife Sciences, 275 WIDB, Provo, UT 84602, United States;2. Brigham Young University, Department of Physiology and Developmental Biology, 575 WIDB, Provo, UT 84602, United States;3. Brigham Young University, Department of Biology, 475 WIDB, Provo, UT 84602, United States;4. Michigan State University, College of Veterinary Medicine, Large Animal Clinical Sciences, East Lansing, MI 48824-1316, United States;1. Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland;2. The Emmes Company LLC, Rockville, Maryland;3. Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;4. Janssen Research and Development LLC, Raritan, New Jersey;1. Department of Earth and Environmental Sciences, University of Kentucky, Lexington, KY, 40506, USA;2. Rockfield Global, Ethos, Kings Road, Prince of Wales Dock, Swansea Waterfront, SA1 8AS, UK;3. BP America, 501 Westlake Park Boulevard, Houston, TX, 77079, USA;1. Department of Cell Biology, Third Military Medical University, Chongqing 400038, China;2. Chongqing Stem Cell Therapy Engineering Technical Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China;1. Department of Anatomy, Embryology and Physiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;2. Biogazelle, Ghent, Belgium;3. Center of Molecular Biology (ZMBH), University of Heidelberg, Heidelberg 69120, Germany |
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| Abstract: | Little is known about the inheritance and influence of the fleece color gene Melanocortin 1 Receptor (MC1R). Melanocortin 1 Receptor (MC1R) is a well-known gene responsible for red versus black fleece pigmentation and is hypothesized to be a candidate gene for variation in alpaca coloration patterns. Inheritance of red versus black pigmentation in the context of genetic mutation is well understood in many domesticated mammals. We characterized the MC1R gene in a population of multi-colored alpacas in order to better understand its effect on coat color in the alpaca. Our characterization of the alpaca MC1R gene revealed 11 mutations. Of these one is a 4 bp deletion, four are silent mutations and six are single nucleotide polymorphisms (SNPs) that alter the amino acid sequence (T28V, M87V, S126G, T128I, S196F, R301C). No mutation correlated completely with fleece color in alpacas at the MC1R locus. This may be due to the epistatic relationship of MC1R with other coat color genes especially agouti signaling protein (ASIP). |
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