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Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage (EXPAH project): description of the population under study |
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| Authors: | Taioli Emanuela Sram Radim J Garte Seymour Kalina Ivan Popov Todor A Farmer Peter B |
| Affiliation: | aUniversity of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA 15232, USA bLaboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, Prague, Czech Republic cGenetics Research Institute ONLUS, Milan, Italy dDepartment of Medical Biology, Medical Faculty University P.J. Safarik, Kosice, Slovak Republic eNational Center of Public Health Protection, Sofia, Bulgaria fCancer Biomarkers and Prevention Group, Biocentre, University of Leicester, UK |
| Abstract: | The EXPAH project was a molecular epidemiology study whose aims were to evaluate the hypothesis that polycyclic aromatic hydrocarbons (PAHs) are a major source of genotoxic activities of organic mixtures associated with air pollution. Biomarkers of exposure, effects and susceptibility, and oxidative DNA damage were measured in three PAH-exposed populations from Prague (Czech Republic), Kosice (Slovakia) and Sofia (Bulgaria). Control populations were included from each city. In total 356 individuals were enrolled. A questionnaire was used to determine life style/dietary factors. Ambient air exposure was measured by stationary monitoring, and personal exposure monitoring was also carried out. The characteristics of the population are described in this paper together with their personal exposure to carcinogenic PAHs (c-PAHs). The dose of c-PAH exposure was found to vary between the occupationally exposed (e.g. policemen and bus drivers) and the control populations in each country, and also varied from country to country. |
| Keywords: | PAH-exposed populations Molecular epidemiology c-PAH |
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