Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy |
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| Authors: | Ghosh Arun K Swanson Lisa M Liu Chunfeng Hussain Khaja Azhar Cho Hanna Walters D Eric Holland Louis Buthod Jim |
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| Affiliation: | Department of Chemistry, University of Illinois at Chicago, 60607, USA. arunghos@uic.edu |
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| Abstract: | A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against HIV-1 protease. |
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