| DNA去甲基化对细胞衰老的影响 |
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| 引用本文： | 毛泽斌,张宗玉,童坦君. DNA去甲基化对细胞衰老的影响[J]. 中国生物化学与分子生物学报, 1997, 13(3): 318-321 |
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| 作者姓名： | 毛泽斌 张宗玉 童坦君 |
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| 作者单位： | 北京医科大学生物化学与分子生物学系衰老分子生物学研究室!北京，100083，北京医科大学生物化学与分子生物学系衰老分子生物学研究室!北京，100083，北京医科大学生物化学与分子生物学系衰老分子生物学研究室!北京，100083 |
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| 基金项目： | 国家自然科学基金!39230330 |
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| 摘 要： | 5-氮杂胞嘧啶（5aZaC）为DNA甲基化转移酶的抑制剂，用它处理细胞，使基因组DNA去甲基化．结果发现，经5aZaC处理后的细胞衰老进程明显加快，这从另一侧面反映了DNA甲基化与细胞衰老的关系．
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| 关 键 词： | DNA去甲基化 细胞衰老 |
| 收稿时间： | 1997-06-20 |
The Effect of Demethylation of Genomic DNA on Cell Aging Process |
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| Mao Ze-Bin,Zhang Zong-Yu,Tong Tan-Jun. The Effect of Demethylation of Genomic DNA on Cell Aging Process[J]. Chinese Journal of Biochemistry and Molecular Biology, 1997, 13(3): 318-321 |
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| Authors: | Mao Ze-Bin Zhang Zong-Yu Tong Tan-Jun |
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| Affiliation: | (Department of Biochemistry and Molecular Biology,Beijing Medical University, Beijing 100083 |
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| Abstract: | Azaceoxycytidine(5aZaC)was known to inhibit the methylation of cytosine in DNA.Their effects on aging process of human fibroblasts, strain 2BS, were examined. The results showed that cell aging process was obviously shortened as judged by DNA replication synthesis, cell morphology and DNA methylation level. The results support the view that the loss of methylgroups in DNA may eventually have deleterious consequence,such as aberrant epigenetic change in gene expression. |
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| Keywords: | DNA demethylation Cell aging |
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