Antimicrobial activity of <Emphasis Type="Italic">Bacillus megaterium</Emphasis> strains |
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| Authors: | I A Malanicheva D G Kozlov I G Sumarukova O V Efremenkova V A Zenkova G S Katrukha M I Reznikova O D Tarasova S P Sineokii G I El’-Registan |
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| Institution: | 1.Gause Institute of New Antibiotics,Russian Academy of Medical Sciences,Moscow,Russia;2.State Research Institute for Genetics and Selection of Industrial Microorganisms,Moscow,Russia;3.Winogradsky Institute of Microbiology,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | A bacterial strain with a high level of antimicrobial activity was isolated from soil and identified as Bacillus megaterium. Production of antibiotics by nine strains of this species from the collection of the State Research Institute for Genetics
and Selection of Industrial Microorganisms was investigated. In submerged cultures, nine out of ten B. megaterium strains were found to produce antibacterial antibiotics differing in their spectra of action. Physicochemical characteristics
of five compounds were described. Three of them belonged to peptide antibiotics. All five compounds were active against the
methicillin-resistant strain Staphylococcus aureus INA 00761. Three of them were shown to be the previously undescribed compounds. Antibiotics produced by various B. megaterium strains were also active against the Leuconostoc mesenteroides VKPM B-4177 strain resistant to glycopeptide antibiotics and against gram-negative bacteria Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922. |
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