Atg22p, a vacuolar membrane protein involved in the amino acid compartmentalization of Schizosaccharomyces pombe |
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| Authors: | Sugimoto Naoko Iwaki Tomoko Chardwiriyapreecha Soracom Shimazu Masamitsu Kawano Miyuki Sekito Takayuki Takegawa Kaoru Kakinuma Yoshimi |
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| Institution: | Department of Applied Bioresource Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan. |
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| Abstract: | The fission yeast Schizosaccharomyces pombe has a homolog of the budding yeast Atg22p, which is involved in spore formation (Mukaiyama H. et al., Microbiology, 155, 3816-3826 (2009)). GFP-tagged Atg22p in the fission yeast was localized to the vacuolar membrane. Upon disruption of atg22, the amino acid levels of the cellular fraction as well as the vacuolar fraction decreased. The uptake of several amino acids, such as lysine, histidine, and arginine, was impaired in atg22Δ cells. S. pombe Atg22p plays an important role in the compartmentalization of amino acids. |
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