Minimal contribution of Valpha14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice |
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| Authors: | Kawakami Kazuyoshi Kinjo Yuki Uezu Kaori Yara Satomi Miyagi Kazuya Koguchi Yoshinobu Nakayama Toshinori Taniguchi Masaru Saito Atsushi |
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| Affiliation: | First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. kawakami@med.u-ryukyu.ac.jp |
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| Abstract: | We elucidated the contribution of Valpha14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Valpha14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-gamma between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Valpha14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection. |
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| Keywords: | NKT cells Th1 response host defense mycobacterial infection |
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