| 消炎痛对五肽胃泌素引起的大鼠胃酸分泌的影响 |
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| 引用本文： | 王德民,王志均.消炎痛对五肽胃泌素引起的大鼠胃酸分泌的影响[J].生理学报,1983(4). |
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| 作者姓名： | 王德民 王志均 |
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| 作者单位： | 北京医学院基础医学研究所消化、生殖生理研究室
(王德民)，北京医学院基础医学研究所消化、生殖生理研究室(王志均) |
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| 摘 要： | 本工作进一步证实了消炎痛对胃泌素刺激胃酸分泌作用并无影响。基本应用 Ghosh 和Schild 的方法,用大鼠进行了急性实验,以恒速将接近体温的生理盐水自食道插管灌流胃,从幽门插管收集流出的灌流液作为胃液样品。结果表明,口服消炎痛(20—50mg/kg)对静脉注射五肽胃泌素(10μg/kg)所引起的胃酸分泌并无任何影响,这一结果与我们在狗身上的观察一致。结合前一工作,我们认为,内源性 PG 不影响胃泌素刺激胃酸分泌的作用,但影响胃泌素的合成和释放,因而内源性 PG 可能参与胃液分泌的调节。
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| 关 键 词： | 胃酸分泌 前列腺素 消炎痛 五肽胃泌素 |
EFFECT OF INDOMETHACIN ON PENTAGASTRIN-INDUCED GASTRIC ACID SECRETION IN THE RAT |
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| WANG TE-MIN AND WANG CHIH-CHUN.EFFECT OF INDOMETHACIN ON PENTAGASTRIN-INDUCED GASTRIC ACID SECRETION IN THE RAT[J].Acta Physiologica Sinica,1983(4). |
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| Authors: | WANG TE-MIN AND WANG CHIH-CHUN |
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| Abstract: | The purpose of this investigation was to clear further the effect of indomethacinon pentagastrin-induced gastric acid secretion.Acute experiment was performedin rats,following essentially the technic of Ghosh and Schild.The stomach of therat was perfused with warm saline at a uniform rate and the perfusate was collect-ed as samples of gastric juice for acid analysis.The results showed that indomethacin(20-50 mg/kg orally)had no effect onpentagastrin-induced gastric acid secretion.The result is consistent with ourprevious observation in the dog,indicating that endogenous prostaglandins aresomewhat involved in the release of gastrin but have no effect on its action oncereleased. |
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| Keywords: | acid secretion prostagmandin indomethacin pentagastrin |
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