Production of B cell stimulatory factor-2/interleukin-6 activity by human endothelial cells |
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| Authors: | K Norioka M Hara M Harigai A Kitani T Hirose K Suzuki M Kawakami H Tabata M Kawagoe H Nakamura |
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| Affiliation: | First Department of Internal Medicine, National Defense Medical College, Saitama, Japan. |
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| Abstract: | The effect of culture supernatants of endothelial cell (EC) lines on the immunoglobulin-M(IgM) synthesis by human B cell line, SKW6-CL4 cells, was investigated. Supernatants of human EC stimulated IgM synthesis, as high as 6-fold, but supernatants of bovine EC did not. This enhancing activity was completely blocked by addition of anti-human B cell stimulatory factor-2/interleukin-6 (BSF-2/IL-6) antibody. These data suggest that human EC might participate in the human antibody production system by producing soluble factor, BSF-2/IL-6. |
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