Substrates and products of fatty acid elongation in mouse brain microsomes] |
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| Authors: | S Pollet J M Bourre G Chaix O Daudu N Baumann |
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| Affiliation: | Laboratoire de Neurochimie, INSERM U 134, Hôpital de la Salpêtrière, 47, boulevard de l''Hôpital, 75634 Paris Cedex 13, France |
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| Abstract: | In brain microsomes, palmitate and stearate elongation involve a membrane lipid-bound substrate. After elongation by malonyl-CoA, acyl-products are partially bound to proteins. Acyl-proteins are not found when endogenous fatty acid elongation takes place. In the dysmyelinating Quaking mouse mutants, "stearyl-membrane" substrate formation is normal; thus, the deficiency observed in very long chain fatty acid formation is not due to a lack in substrate formation. |
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| Keywords: | A qui toute correspondance doit être adressée. |
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