Tumour–stroma interactions in carcinogenesis: Basic aspects and perspectives |
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Authors: | Kiaris H. Chatzistamou I. Kalofoutis Ch. Koutselini H. Piperi Ch. Kalofoutis A. |
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Affiliation: | (1) Departments of Biological Chemistry, Medical School, University of Athens, 115 27 Athens, Greece;(2) Departments of Pathology, Medical School, University of Athens, 115 27 Athens, Greece;(3) Departments of Cytopathology, Medical School, University of Athens, 115 27 Athens, Greece |
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Abstract: | In contrast to the conventional notion regarding tumour development as a cell autonomous process in which the major participants were the cancer cells, increasing evidence attributes important role in the stromal components, namely fibroblasts, and view the tumour as a heterogenous mixture of different cell types. These different types of cells, being cancer cells, fibroblasts, endothelial cells, and others, interact reciprocally and play an almost equally important role in the manifestation of certain aspects of the malignant phenotype. The elucidation of the mechanistic base of such interactions, besides the contribution to understand fundamental aspects of tumour cell biology, promises important applications in diagnosis, prognosis and therapy of the disease. (Mol Cell Biochem 261: 117–122, 2004) |
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Keywords: | carcinogenesis stroma fibroblasts non-autonomy effects |
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