Cloning and characterization of a novel synaptosome-enriched mRNA that encodes 31 kDa protein |
| |
Authors: | Ishimoto Tetsuya Ninomiya Kensuke Miyaji Kazue Uyeda Atsuko Kasai Michiki Taguchi Takahisa |
| |
Institution: | Neuronics Research Group, Special Division for Human Life Technology, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31, Midorigaoka, Ikeda, Japan. |
| |
Abstract: | Although a subpopulation of mRNAs has been identified as translocated to the dendrites or the synaptic regions of neurons, the translocational mechanism has not been elucidated. To find mRNAs enriched in synapses, we compared the synaptosomal mRNAs with those from whole forebrain using differential display (DD). We cloned one of these mRNAs, which encoded a novel 31 kDa protein (PMES-2). PMES-2 mRNA was specifically transcribed in the brain and was present in the dendrites of the hippocampal neurons. PMES-2 protein was partly localized in the postsynaptic density. Although this protein is very similar to human NABC1 protein, its function is still unknown. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|