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Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption |
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| Authors: | Cornelis Marilyn C Monda Keri L Yu Kai Paynter Nina Azzato Elizabeth M Bennett Siiri N Berndt Sonja I Boerwinkle Eric Chanock Stephen Chatterjee Nilanjan Couper David Curhan Gary Heiss Gerardo Hu Frank B Hunter David J Jacobs Kevin Jensen Majken K Kraft Peter Landi Maria Teresa Nettleton Jennifer A Purdue Mark P Rajaraman Preetha Rimm Eric B Rose Lynda M Rothman Nathaniel Silverman Debra Stolzenberg-Solomon Rachael Subar Amy Yeager Meredith Chasman Daniel I van Dam Rob M Caporaso Neil E |
| Institution: | Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America. |
| Abstract: | We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. |
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