Opsonizing effect of serum and albumin gland extracts on the elimination of human erythrocytes from the circulation of Helix pomatia |
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Authors: | L Renwrantz W Mohr |
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Affiliation: | 1. Institute for Pathobiology, Center for Health Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA;2. Zoologisches Institut und Zoologisches Museum der Universität Hamburg, Martin-Luther-King-Platz 3, 2 Hamburg 13, West Germany |
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Abstract: | The removal of human erythrocytes of the A1 and B types from the circulation of the gastropod Helix pomatia follows an exponential curve. The elimination of the nonself particles is apparently dependent on serum opsonins as preincubation of A1 and B erythrocytes in Helix serum increases the rate of their clearance. This conclusion is supported by our finding that secondary doses of nonsensitized A1 erythrocytes injected 12–19 hr after a similar primary dose are cleared very slowly; however, the clearance rate returns to normal if erythrocytes comprising the second dose are preincubated with Helix serum. Furthermore, the elimination of second-dose A1 erythrocytes is strongly enhanced after their pretreatment with agglutinating extracts of the albumin glands from H. pomatia and Cepaea (Helix) nemoralis. On the other hand, no opsonizing effect was obtained by pre-incubating A1 erythrocytes in the agglutinating extract of the sponge Aaptos papillata. |
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Keywords: | human erythrocytes serum opsonin albumin glands kinetics serum opsonizing effect |
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