Modulation of Mn2+ accumulation in cultured rat neuronal and astroglial cells |
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Authors: | G. Tholey L. Megias-Megias F. C. Wedler M. Ledig |
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Affiliation: | (1) Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France;(2) Faculty of Medicine, University of Granada, 18071 Granada, (Spain);(3) Department of Molecular and Cell Biology, The Pennsylvania State University, 16802 University Park, PA, (USA) |
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Abstract: | The effects of physiological concentrations of K+ on Mn2+ accumulation were compared in rat glial cells and neurons in culture. Increasing the K+ concentration in growth medium increased significantly the Mn2+ level of the cultivated cells, with glial cells more affected than neurons. Ethanol markedly increased the Mn2+ accumulation within glia but not within neurons while ouabaïn caused inhibition of Mn2+ uptake with neurons and glial cells. A modulation of the total protein synthesis by Mn2+ and ethanol level in the growth medium was observed with glial cells. These data suggest that the mechanisms involved in Mn2+ accumulation in glial cells are different from those present in neurons. Moreover, the results are consistent with the hypothesis that Mn2+ plays a regulatory role in glial cell metabolism. |
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Keywords: | Glial cells Neurons Mn2+ accumulation K+-effect trace elements |
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