滇产回心草及回心康抗缺血心肌脂质过氧化作用及对前列环素／血栓素的影响

采用结扎大鼠冠脉造成急性心肌缺血模型,动态观测Ⅱ导联心电图ST段的变化,以S-T段上移为指标反映缺血程度,观察了滇产回心草及回心康对急性心肌缺血损伤的保护作用,同时检测血清SOD、MDA、PGI2和TXA2.结果表明,回心草及回心康均能显著减少S-T段上移,均以2 g/kg组为显著;其1 g/kg及2 g/kg均使心肌梗塞范围缩小(p＜0.05,p＜0.01);均使心肌缺血大鼠血清SOD显著提高(p＜0.05及p＜0.01);MDA显著降低(p＜0.05,p＜0.01).回心草及回心康还能提高大鼠血清PGI2水平,降低TXA2含量,以回心草2 g/kg及回心康2 g/kg为显著(p＜0.05),呈剂量依赖性.实验结果提示,回心草及回心康均具有抗心肌缺血及抗脂质过氧化作用,其提高PGI2/TXA2可能与其抗心肌缺血作用机制有关.

PROTECTIVE EFFECTS OF RHODOBRYUM ROSEUM (HEDW) LIMPR. OR HXK TABLETS ON LIPID PEROXIDATION, PROSTACYCLIN AND THROMBOXANE A2 ON MYOCARDIAL ISCHEMIA RATS

Rhodobryum Roseum(Hedw.)Limpr.consists of the dried or fresh herba which belongs to the Rhodobryum plant in Braceae in Yunnan Province.HXK tablets are traditional Chinese complex medicine which consists of major contents from Rhodobryum Roseum(Hedw.)Limpr.They were used to treat of coronary heart disease in folk.In this paper,it was studied their protecting effects against ischemia injury and their mechanics.An experimental acute myocardial ischemia model by ligated left coronary artery on rats was made,in which S-T sigments of ECG,superoxide dismutase(SOD),malondialdehyde(MDA),prostacyclin(PGI 2),thromboxane A 2(TXA 2)of serum levels were detected.Roseum or HXK at 1 g/kg and 2 g/kg significantly increased SOD activities(P<0.05 or P<0.01),reduced MDA products (P<0.05 or P<0.01).Ruseum or HXK at 2 g/kg increased PGI 2 levels(P<0.05),HXK at 2 g/kg also decreased TXA 2 levels.The results showed that Roseum or HXK can protect against cardiac ischemia injury.The effects were considered to relate to the inhibitions of lipid peroxidation and increases PGI 2/TXA 2.