Impact of high energy resolution detectors on the performance of a PET system dedicated to breast cancer imaging |
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| Affiliation: | 1. Department of Biomedical Engineering, University of California, Davis, CA 95616, USA;2. Institute of Medical Device and Imaging, College of Medicine, National Taiwan University, No.1, Sec. 1, Jen Ai Rd., Zhongzheng Dist., Taipei City 100, Taiwan;1. Department of Radiation Convergence Engineering, Yonsei University, Wonju 220-710, Republic of Korea;2. Department of Bio-convergence Engineering, Korea University, Seoul 136-701, Republic of Korea;3. Molecular Imaging Research Center, Korea Institute of Radiological and Medical Science, Seoul 139-706, Republic of Korea;4. Nucare Medical System, Inc., Incheon 406-840, Republic of Korea;1. Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiation Physics, Bautzner Landstraße 400, 01328, Germany;2. OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Germany;3. Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology, Bautzner Landstraße 400, 01328 Dresden, Germany;4. German Cancer Consortium (DKTK), Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany;5. CAEN S.p.A., Viareggio, Italy;6. now with Institute of Nuclear and Particle Physics, AG Radiation Physics, Technische Universität Dresden, Dresden, Germany |
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| Abstract: | We are developing a high resolution, high sensitivity PET camera dedicated to breast cancer imaging. We are studying two novel detector technologies for this imaging system: a scintillation detector comprising layers of small lutetium oxyorthosilicate (LSO) crystals coupled to new position sensitive avalanche photodiodes (PSAPDs), and a pure semiconductor detector comprising cadmium zinc telluride (CZT) crystal slabs with thin anode and cathode strips deposited in orthogonal directions on either side of each slab. Both detectors achieve 1 mm spatial resolution with 3–5 mm directly measured photon interaction depth resolution, which promotes uniform reconstructed spatial resolution throughout a compact, breast-size field of view. Both detector types also achieve outstanding energy resolution (<3% and <12%, respectively for LSO-PSAPD and CZT at 511 keV). This paper studies the effects that this excellent energy resolution has on the expected system performance. Results indicate the importance that high energy resolution and narrow energy window settings have in reducing background random as well as scatter coincidences without compromising statistical quality of the dedicated breast PET data. Simulations predict that using either detector type the excellent performance and novel arrangement of these detectors proposed for the system facilitate ∼20% instrument sensitivity at the system center and a peak noise-equivalent count rate of >4 kcps for 200 microCi in a simulated breast phantom. |
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