Analysis of a novel offset cone-beam computed mammotomography system geometry for accomodating various breast sizes |
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| Institution: | 1. Department of Radiology, Duke University Medical Center, Durham (NC, USA) 27710;2. Department of Biomedical Engineering, Duke University, Durham (NC, USA) 27710;3. Department of Physics, Duke University, Durham (NC, USA) 27710;1. Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany;2. Radiological Sciences Lab, Stanford University, United States;3. Computer Aided Medical Procedures, Johns Hopkins University, United States;1. Mayo Clinic, Rochester, Minnesota;2. Winter Haven Hospital, University of Florida, Winter Haven, Florida;3. Tulane University School of Medicine, New Orleans, Louisiana;1. Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh 160012, India;2. Department of Pulmonary Medicine, PGIMER, Chandigarh 160012, India;1. Department of Radiology, Cancer Center and Institute of Oncology M. Sklodowska-Curie Memorial, Warsaw, Poland;2. Institute of Fundamental Technological Research, PAS, Warsaw, Poland;3. Department of Pathology, Cancer Center and Institute of Oncology M. Sklodowska-Curie Memorial, Warsaw, Poland;4. Department of Imaging Diagnostic, Medical University of Warsaw, Poland;1. Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida;2. Biostatistics and Bioinformatics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida;3. Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida;4. Department of Urology, University of Miami Miller School of Medicine, Miami, Florida;1. National Coordinating Centre for the Physics in Mammography (NCCPM), Level B, St Luke’s Wing, Royal Surrey County Hospital, Guildford GU2 7XX, UK;2. Department of Physics, University of Surrey, Guildford GU2 7XH, UK;3. Clinical Trials and Statistical Unit, Institute of Cancer Research, London SW7 3RP, UK |
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| Abstract: | We evaluate a newly developed dedicated cone-beam transmission computed mammotomography (CmT) system configuration using an optimized quasi-monochromatic cone beam technique for attenuation correction of SPECT in a planned dual-modality emission and transmission system for pendant, uncompressed breasts. In this study, we perform initial CmT acquisitions using various sized breast phantoms to evaluate an offset cone-beam geometry. This offset geometry provides conjugate projections through a full 360 degree gantry rotation, and thus yields a greatly increased effective field of view, allowing a much wider range of breast sizes to be imaged without truncation in reconstructed images. Using a tungsten X-ray tube and digital flat-panel X-ray detector in a compact geometry, we obtained initial CmT scans without shift and with the offset geometry, using geometrical frequency/resolution phantoms and two different sizes of breast phantoms. Acquired data were reconstructed using an ordered subsets transmission iterative algorithm. Projection images indicate that the larger, 20 cm wide, breast requires use of a half-cone-beam offset scan to eliminate truncation artifacts. Reconstructed image results illustrate elimination of truncation artifacts, and that the novel quasi-monochromatic beam yields reduced beam hardening. The offset geometry CmT system can indeed potentially be used for structural imaging and accurate attenuation correction for the functional dedicated breast SPECT system. |
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