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T cell growth factors from adult T cell leukemia virus-transformed cell lines
Authors:Y Okai  T Oka  T Akagi  S Kurata  N Fujiyoshi
Institution:1. Tokyo Research Lab., Kyowa Hakko Kogyo Co., Ltd., Asahimachi, Machida, Tokyo 194, Japan;2. Department of Pathology, Kochi Medical School, Kochi 781-51, Japan
Abstract:Some characteristics of T cell growth factors derived from adult T cell leukemia virus (ATLV)-transformed cell lines, MT 1 and MT 2 were analyzed. MT 1 cells release significant interleukin 2 (IL 2) activity into the culture medium, which showed the same elution pattern of gel filtration and isoelectric focusing of IL 2 from lectin-stimulated normal human lymphocytes. This activity was also detected in the cell extract of MT 1. In contrast, MT 2 cell line did not produce IL 2 activity, but non-IL 2 type growth factor was observed. The significance of these factors from MT cell lines is discussed from the viewpoint of 'autokine' in ATLV-transformed cells.
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