Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults |
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Authors: | Eri Miyamoto-Mikami Koji Sato Toshiyuki Kurihara Natsuki Hasegawa Shumpei Fujie Satoshi Fujita Kiyoshi Sanada Takafumi Hamaoka Izumi Tabata Motoyuki Iemitsu |
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Affiliation: | 1. Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.; 2. Japan Society for the Promotion of Science, Tokyo, Japan.; Medical University Innsbruck, AUSTRIA, |
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Abstract: | To elucidate the effects of endurance training on circulating irisin levels in young and middle-aged/older adults, and to determine the association between endurance training-induced alteration of irisin and reduction in body fat. Twenty-five healthy young (age 21 ± 1 years; 16 men, 9 women) and 28 healthy middle-aged/older adults (age 67 ± 8 years; 12 men, 16 women) participated in the study. Each age cohort was divided into two groups: the endurance-training group (14 young, 14 middle-aged/older) and the control group. Subjects in the training groups completed an 8-week endurance-training program (cycling at 60-70% peak oxygen uptake [O2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated serum irisin level, O2peak, and body composition. The increase in O2peak in the young and middle-aged/older training groups after the intervention period was significantly greater than those in the young and middle-aged/older control groups (P < 0.05). Serum irisin level was significantly increased in the middle-aged/older training group after the intervention period (P < 0.01), but not in the young training group. Furthermore, in the middle-aged/older training group, the endurance training-induced reduction in visceral adipose tissue area was negatively correlated with the change in serum irisin level (r = −0.54, P < 0.05). These results suggest a possible role for secreted irisin in the exercise-induced alteration of abdominal visceral fat in middle-aged and older adults. |
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