The extent of linkage disequilibrium and haplotype sharing around a polymorphic site |
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Authors: | Innan Hideki Nordborg Magnus |
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Affiliation: | Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089-1340, USA. hinnan@sph.uth.tmc.edu |
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Abstract: | Various expressions related to the length of a conserved haplotype around a polymorphism of known frequency are derived. We obtain exact expressions for the probability that no recombination has occurred in a sample or subsample. We obtain an approximation for the probability that no recombination that could give rise to a detectable recombination event (through the four-gamete test) has occurred. The probabilities can be used to obtain approximate distributions for the length of variously defined haplotypes around a polymorphic site. The implications of our results for data analysis, and in particular for detecting selection, are discussed. |
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