Esterase-8 (Es-8): Characterization,polymorphism, and linkage of an erythrocyte esterase locus on chromosome 7 of Mus musculus |
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Authors: | Verne M Chapman Elizabeth A Nichols Frank H Ruddle |
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Institution: | 1. Department of Molecular Biology, Roswell Park Memorial Institute, Buffalo, New York 2. Department of Biology, Yale University, New Haven, Connecticut
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Abstract: | An electrophoretic polymorphism of an erythrocyte esterase, esterase-8, specific for the substrates α- and β-naphthyl acetate has been observed in the Asian house mouse, Mus musculus castaneus. M. m. castaneus is interfertile with inbred strains of mice, and F1 hybrids (C57BL/6J × castaneus)F1 and (SWR/J × castaneus)F1 show a double-banded phenotype similar to a mixture of parental forms. This pattern suggests codominant expression of a structural gene difference. In backcrosses, ES-8 segregated as a single autosomal gene, designated Es-8, linked to Gpi-1 on chromosome 7. A gene order of Es-8, Gpi-1, c, Mod-2, and Hbb was determined from a series of crosses. |
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