持续正压通气治疗阻塞性睡眠呼吸暂停综合征并发心房纤颤的临床研究

目的:研究持续正压通气治疗阻塞性睡眠呼吸暂停综合征(OSAHS)并发心房纤颤的临床疗效。方法:选取2013年1月到2014年1月我院收治的OSAHS并发心房纤颤患者60例,按照随机数字表法将患者分为实验组和对照组,每组30例。对照组给予常规治疗,实验组在对照组的基础上给予持续正压通气治疗,两组均治疗1年。分析治疗前、后两组心率(HR)、血氧饱和度(SPO2)、左心射血分数(LVEF)、脑钠肽(BNP),并比较两组心房纤颤转复率、复发率和不良反应。结果:治疗后实验组HR、SPO2、LVEF以及BNP显著优于对照组,两组比较差异具有统计学意义(P0.05);治疗后实验组心房纤颤转复率显著高于对照组,心房纤颤复发率显著低于对照组,两组比较差异具有统计学意义(P0.05);两组不良反应发生率比较无统计学意义(P0.05)。结论:持续正压通气治疗OSAHS并发心房纤颤具有较好的效果,有利于改善心功能,提高心房纤颤转复率降低房纤颤复发率。

Obstructive Sleep Apnea Syndrome Complicated Atrial Fibrillation: Clinical Research of Continuous Positive-pressure Ventilation Therapy

Objective:To study the clinical efficacy of continuous positive-pressure ventilation in treatment of obstructive sleep apnea syndrome (OSAHS) complicated atrial fibrillation.Methods:A total of 60 patients with OSAHS complicated atrial fibrillation,who were admitted to Wuhan Third Hospital from January 2013 to January 2014, were selected and randomly divided into experiment group (n=30) and control group (n=30). The control group was treated with conventional therapy, on the basis of which the experiment group was added continuous positive-pressure ventilation. The duration of treatment of two groups was 1 year. The heart rate (HR), oxygen saturation (SPO2), left ventricular ejection fraction (LVEF), brain natriuretic peptide (BNP) in the two groups before and after treatment were analyzed . The cardioversion rate and recurrence rate of atrial fibrillation,and the adverse reactions in the two groups were compared.Results:HR, SPO2, LVEF and BNP in the experiment group after treatment were significantly better than those in the control group, the differences were statistically significant (P<0.05). Cardioversion rate of atrial fibrillation in the experiment group after treatment was significantly higher than that in the control group, and the recurrence rate of atrial fibrillation was significantly lower than that in the control group, the differences were all statistically significant (P<0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Continuous positive-pressure ventilation has a good efficacy in the treatment of patients with OSAHS complicated atrial fibrillation, which is helpful in improving the heart function, increasing cardioversion rate and cutting down the recurrence rate of atrial fibrillation.