高危型HPV筛查与TCT 联合检查在宫颈癌筛查中的临床应用 |
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引用本文: | 孙娟娟 宋晓婕 罗自娟 夏红慧 袁娟. 高危型HPV筛查与TCT 联合检查在宫颈癌筛查中的临床应用[J]. 现代生物医学进展, 2016, 16(12): 2336-2338 |
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作者姓名: | 孙娟娟 宋晓婕 罗自娟 夏红慧 袁娟 |
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作者单位: | 武汉市商业职工医院妇产科;武汉市妇女儿童医疗保健中心妇产科 |
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摘 要: | 目的:探究液基薄层细胞学检测(TCT)与高危人乳头瘤病毒(HR-HPV)筛查联合检查在宫颈癌(CC)筛查中的临床价值。方法:选择2013年4月~2015年4月期间我院就诊疑似CC患者318例为研究对象;研究对象均进行HR-HPV筛查、TCT检查及阴道镜下病理活检,评价三种筛查结果的临床应用价值。结果:318例可疑CC患者中,病理学诊断炎症患者162例(50.94%),宫颈上皮内瘤样变(CIN)患者151例(47.48%),鳞癌(SCC)患者5例(1.57%);HR-HPV、TCT及HPV+TCT联合对诊断结果与病理诊断的符合率分别为78.30%、85.22%和99.37%;HR-HPV与TCT单独检测的符合率随患者病情进展呈现升高趋势(P0.05);TCT、HR-HPV检测单独进行诊断的敏感度、特异度均低于联合诊断(P0.05);HR-HPV与TCT联合检测诊断CC的敏感度为98.71%、特异度100%。结论:TCT检查HR-HPV筛查联合检查CC的敏感性、特异性及准确性高,为CC筛查的有效方式,值得在临床应用推广。
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关 键 词: | 高危人乳头瘤病毒;薄层液基细胞学;宫颈癌;病理学诊断 |
Clinical Application of HR-HPV Combined with TCT in Screening ofCervical Cancer |
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Abstract: | Objective:To explore the clinical application value of high risk-human papilloma virus (HR-HPV) combined with thincytologic test (TCT) in screening of patients with cervical cancer (CC).Methods:A total of 318 patients with suspected CC, who weretreated in Wuhan Commercial Staff Hospital from April 2013 to April 2015, were chosen as research subjects. All the subjects weregiven HR-HPV, TCT screening,and pathologic biopsy under vaginoscopy. The clinical application value of the three screening methodswas evaluated.Results:The pathological results showed that there were 162 patients with inflammation (50.94%), 151 patients withcervical intraepithelial neoplasia (CIN)(47.48%) and 5 patients with squamous cell carcinomas (SCC)(1.57%) among the 318 suspectedpatients. The coincidence rate of HR-HPV, TCT and HPV+TCT and pathological results were 78.30%, 85.22%and 99.37%respectively.The coincidence rate of HR-HPV and TCT screening were increased with the severity of disease (P<0.05).The sensitivity (98.71%) andspecificity (100%) of HPV+TCT were significantly higher than TCT, HR-HPV screening separately (P<0.05).Conclusion:HR-HPVcombined with TCT screening has high sensitivity, specificity and accuracy in the screening of patients with CC, which is an effectiveway for CC screening and worth popularizing in clinical application. |
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Keywords: | High risk-human papilloma virus Thin cytologic test Cervical cancer Pathological diagnosis |
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