常见肝炎病毒感染性疾病相关miRNA功能研究进展 |
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引用本文: | 欧阳晓希 顾大勇 张少波 田彩明 蒋鑫 谢伟东. 常见肝炎病毒感染性疾病相关miRNA功能研究进展[J]. 现代生物医学进展, 2016, 16(8): 1573-1578 |
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作者姓名: | 欧阳晓希 顾大勇 张少波 田彩明 蒋鑫 谢伟东 |
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作者单位: | 清华大学深圳研究生院生命与健康学部健康科学与技术重点实验室;中山大学公共卫生学院卫生检验与检疫系;深圳市检验检疫科学研究院;南方医科大学第二临床分委会珠江医院 |
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基金项目: | 深圳市科技研发资金-深港协同创新圈基金资助(SGLH20121008144756945);国家自然科学基金项目(81373460,81072680) |
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摘 要: | 病毒感染引发的疾病一直威胁着人类健康。Mi RNA是真核生物表达的一类重要的小分子RNA,可特异性的调节基因与蛋白的表达。mi RNA的研究为病毒性疾病的发生发展提供了新思路,为目前热点研究领域。随着mi RNA的研究深入,一些病毒感染中相关mi RNA的功能也被相继报道,如有些mi RNA具有抑制病毒感染宿主细胞的功能,有些mi RNA则可促进病毒在宿主细胞中的复制,有些mi RNA却参与病毒相关疾病的发生,还有些mi RNA则可作为病毒感染性疾病的特异性生物标志物。本文主要以两种常见肝炎病毒:HBV、HCV为例来系统阐述mi RNA在病毒感染中的相关功能。
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关 键 词: | 病毒;微小核酸;乙型肝炎病毒;丙型肝炎病毒 |
The Research Progress for the Function of MiRNAs Associated withCommon Hepatitis Virus Infectious Diseases |
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Abstract: | The diseases caused by viruses have been threatening human health. MiRNAs are a kind of important small RNAsexpressed in eukaryotes, which can modulate gene expressions and protein translations specifically. As the current hot spot of research,miRNAs provide a new way to explore viral diseases. With the development of miRNA research, lots of miRNAs related to virusinfections have also been reported in succession, such as some miRNAs can inhibit the virus invasion of host cells, some miRNAs canpromote the virus replication in host cells, some miRNAs are involved in virus-related diseases, and even some miRNAs was served asspecific biomarkers of virus infectious diseases. In this paper, we systematically review the functions of miRNAs in common hepatitisvirus B and C infectious diseases, respectively. |
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Keywords: | Virus miRNAs Hepatitis virus B Hepatitis virus C |
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