辛伐他汀联合低分子肝素对慢性心衰心肺功能及相关指标的影响

目的:探索辛伐他汀联合低分子肝素对慢性心力衰竭(CHF)患者的D-二聚体、N-末端脑钠肽前体(NT-proBNP)、左室射血分数(LVEF)、左室舒末内径、血清反应蛋白(CRP)、血浆纤维蛋白原(FB)、血清总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)的影响。方法:选择我院自2010年4月至2014年7月间收治的患有CHF患者80例,按照随机数表法分成治疗组和对照组,各40例。两组均给予常规治疗,治疗组在常规治疗的基础上加用辛伐他汀和低分子肝素,治疗两个月。对比两组患者治疗前后D-二聚体、NT-proBNP、LVEF、左室舒末内径、CRP、FB、TC和LDL-C水平。结果:与治疗前相比,对照组患者治疗后的D-二聚体、NT-proBNP、LVEF、左室舒末内径、CRP、FB、TC和LDL-C水平均无明显改善,而治疗组患者上述各项指标均显著改善,差异均具有统计学意义(均P0.05)。结论:临床上应用辛伐他汀联合低分子肝素可以有效改善CHF患者的相关指标,对于疾病的治疗具有重要作用,值得在临床上应用及推广。

Influence of Simvastatin plus Low Molecular Heparin on Cardiopulmonary Function and Relevant Indexes in Chronic Heart Failure

Objective:To explore the influence of simvastatin plus low molecular heparin on D-dimer, N-terminal brain natriuretic peptide precursor(NT-proBNP), left ventricular ejection fraction(LVEF), left ventricular end-diastolic diameter, serum c-reactive protein (CRP), plasma fibrinogen (FB), serumtotal cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in patients with chronic heart failure (CHF).Methods:A total of 80 patients with CHF, who were treated in Dalian Center Hospital fromApril 2010 to July 2014 ,were selected and randomly divided into treatment group (n=40) and control group (n=40). The two groups were all treated with conventional therapy, based on which, the treatment group was added simvastatin plus low molecular heparin, the course of treatment was two months. The levels of D-dimer, NT-proBNP, LVEF, left ventricular end-diastolic diameter, CRP, FB, TC and LDL-C in the two groups before and after treatment were compared.Results:Compared with before treatment, the levels of D-dimer, NT-proBNP, LVEF, left ventricular end-diastolic diameter, CRP, FB, TC and LDL-C in the control group after treatment were not obviously improved, while the above indexes in the treatment group were improved significantly, the differences were statistically significant(P<0.05).Conclusion:Simvastatin plus low molecular heparin can effectively improve the relevant indexe of patients with CHF, which plays an important role in the clinical treatment and is worthy of clinical application.