Hyper-CVAD/MA治疗复发或难治性弥漫大B 细胞淋巴瘤的临床研究 |
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引用本文: | 傅媛媛 肖青 刘芬 吴昊 罗国平. Hyper-CVAD/MA治疗复发或难治性弥漫大B 细胞淋巴瘤的临床研究[J]. 现代生物医学进展, 2016, 16(10): 1894-1897 |
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作者姓名: | 傅媛媛 肖青 刘芬 吴昊 罗国平 |
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作者单位: | 重庆医科大学附属第一医院血液内科 |
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基金项目: | 重庆市卫生局重点项目课题(2013-1-013) |
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摘 要: | 目的:探讨Hyper-CVAD/MA方案治疗复发或难治弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)的疗效及安全性。方法:观察26例经系统化疗后复发或难治的DLBCL患者接受Hyper-CVAD/MA方案化疗,21-28天为1周期,连续2个周期评价疗效及安全性,分析生存情况。结果:全组26例患者中,总有效率为46.15%,其中完全缓解(complete remission,CR)3例(11.54%),部分缓解(partial remission,PR)9例(34.61%),全组患者中位生存时间为10(2-25)个月,1年和2年总生存率分别为28.57%、14.29%。不良反应主要表现为III-IV度骨髓抑制及继发的肺部感染,其他包括胃肠道反应、口腔炎、肝功能异常等。结论:Hyper-CVAD/MA治疗复发难治DLBCL有一定的疗效,且患者可耐受,可作为二线方案的一个选择。
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关 键 词: | 弥漫大B细胞淋巴瘤;复发/难治;Hyper-CVAD/MA 方案 |
The Efficacy and Safety of Hyper-CVAD/MA Regimen in the Treatment ofRecurrent or Refractory Diffuse Large B-cell Lymphoma |
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Abstract: | Objective:To evaluate the clinical efficacy and safety of Hyper-CVAD/MA regimen in patients with recurrent orrefractory diffuse large B-cell lymphoma (DLBCL).Methods:All 26patients with recurrent or refractory DLBCL were treated withHyper-CVAD/MA regimen after routine treatment. 21-28 days consisted of one cycle, and the therapeutic efficacy and adverse effectwere observed after two cycles.Results:In 26 cases, the overall response rate was 46.15 %. Three patients (11.54 %) achieved a completeremission and9 (34.61 %) achieved a partial remission. The median time of the OS (overall survival) was 10 months. The one-year OSrate and two-year OS rate were 28.57 % and 14.29 %, respectively. Myelosuppression and infection were the major adverse reaction.Other side effects included gastroenteric reactions, oral mucosa inflammation, damage of live function was also observed.Conclusion:Hyper-CVAD/MA regimen can achieve a satisfied result in the treatment of recurrent or refractory DLBCL, and the toxicity wastolerable. |
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Keywords: | Diffuse large B-cell lymphoma Recurrent Refractory Hyper-CVAD/MA regimen |
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