耐药性结核性脑膜炎研究进展

结核性脑膜炎是由结核杆菌引起的中枢感染性疾病,是肺外结核病中最严重的一种,其多侵袭脑膜,有时可累及脑实质、脊髓,有很高的致死率。结核病在发展中国家中的感染趋势尤为突出。我国为人口大国,抗结核治疗和预防的形势异常严峻。随着抗结核药物的广泛使用,耐药性结核性脑膜炎患者数量增加,严重影响了结核性脑膜炎的预后。在耐药性结核性脑膜炎患者的治疗中,早期诊断、经验性治疗、调整治疗方案对患者的预后尤为重要。本文对耐药性结核性脑膜炎的分布、临床诊断、基因检测、治疗方案及预后进行系统性的总结。

Clinical Research Progress of Drug-resistance of Tuberculous Meningitis

Tuberculous meningitis, one of the most serious cases of pulmonary tuberculosis, is a central infectious disease causedby Mycobacterium tuberculosis. It has a high rate of death. Tuberculosis infection is particularly prominent in developing countries. As apopulous country, the situation of anti TB treatment and prevention is very serious. With the widespread use of anti TB drugs, the numberof patients with drug-resistant tuberculosis meningitis is increasing, seriously affect the prognosis of tuberculous meningitis. In the treatmentof patients with drug-resistant tuberculosis meningitis, early diagnosis, empirical treatment, adjust the treatment plan is particularlyimportant for the prognosis of patients. In this paper, the distribution, clinical diagnosis, gene detection, treatment and prognosis of drugresistant tuberculosis meningitis are summarized systematically.