rt-PA静脉溶栓治疗急性大脑中动脉脑梗死的临床疗效

目的:探讨rt-PA静脉溶栓治疗在急性大脑中动脉脑梗死的临床疗效及安全性。方法:选取我院急性大脑中动脉脑梗死患者70例,随机分为实验组和对照组,每组35例。对照组给予保护神经、清除自由基及抗血小板抑制等治疗,实验组在对照组基础上联合阿替普酶静脉滴注。观察并比较治疗前后两组患者血清BNP,CRP及NSE水平的变化情况,以及临床疗效和并发症的发生率。结果:与治疗前相比,治疗后两组患者血清BNP,CRP及NSE水平均降低,差异具有统计学意义(P0.05);与对照组比较,实验组患者治疗后血清BNP,CRP及NSE水平较低,差异具有统计学意义(P0.05);实验组总有效率(85.71%)明显高于对照组(65.71%),差异具有统计学意义(P0.05)。两组患者颅内出血、再灌注损伤、血管再闭塞等并发症的发生率比较,差异无统计学意义(P0.05)。结论:rt-PA静脉溶栓治疗急性大脑中动脉脑梗死的临床疗效显著,能够降低患者血清BNP,CRP及NSE水平。

Clinical Efficacy and Safety of rt-PA Intravenous Thrombolysis in theTreatment of Acute Middle cerebral Artery Infarction

Objective:To investigate the clinical efficacy and safety of rt-PA intravenous thrombolysis on the treatment of acutemiddle cerebral artery infarction.Methods:70 cases with acute middle cerebral artery infarction fromour hospital were collected and randomlydivided into the experiment group and control group, with 35 cases in each group. The patients in the control group were treatedwith regular methods, while the patients in the experiment group were treated with alteplase intravenous thrombolysis. Then the serumlevels of BNP, CRP and NSE, and the clinical efficacy and the incidence of complications between the two groups were observed andcompared before and after treatment.Results:Compared with before treatment, the serumlevels of BNP, CRP and NSE in the two groupsdecreased after treatment, and the differences were statistically significant (P<0.05); Compared with the control group after treatment, theserumlevels of BNP, CRP and NSE in the experiment group were lower, and the differences were statistically significant (P<0.05); Theclinical efficacy rate in the experiment group was 85.71%which was higher than 65.71%in the control group, and the difference was statisticallysignificant (P<0.05); There was no statistically significant about the incidence of adverse reactions between the two groups (P>0.05);Conclusion:rt-PA intravenous thrombolysis has good clinical efficacy in the treatment of acute middle cerebralartery infarction,which can reduce the serumlevels of BNP, CRP and NSE.