富亮氨酸胶质瘤失活1蛋白抗体脑炎的病理特征及临床分析（附1 例案例报道）

目的:探索富亮氨酸胶质瘤失活1蛋白(LGI1)抗体相关自身免疫性脑炎的临床特点及治疗。方法:报道l例LG I1抗体阳性相关自身免疫性脑炎的临床资料,并结合相关文献讨论该病的临床病理特点。结果:老年男性,亚急性起病,反复多次发作并进行性加重,以近记忆下降、癫痫、认知和睡眠障碍为主要表现;头颅MRI示脑萎缩;LGI1抗体阳性。结论:本病患者具有认知功能、睡眠障碍及癫痫等,血清和脑脊液中抗LGI1抗体阳性,但无低钠血症,头颅影像学检查正常;急性发作期给予免疫抑制剂治疗后可获良好效果。

A Case Report of Leucine-rich Glioma Inactivated 1 Protein AntibodyAssociated Autoimmune Encephalitis and Literature Review

Objective:To explore the clinical feature and therapy of leucine-rich glioma inactivated 1 protein antibody associatedautoimmune encephalitis (Ant i-LGI1 AE).Methods:The clinical data of1 case of patient with positive Anti-LGI1 antibody positive patientwas reported, and the clinical features of Ant i-LGI1 AE was summarized with.Results:The patient is 71 years old who was admittedto the hospital due to the subacute symptoms of memory impairment, epilepsy as well as sleep disorder. MRI examination showedbrain atrophy; and antibody against LGI1 in blood and cerebrospinal fluid was positive.Conclusion:Anti-LGI1 antibody positive encephalitispatients usually had cognitive impairment, sleep disorder, epilepsy, serum and positive CSF LG I1 antibody. In addition, patientsoften had no hyponatremia, and their cranial imaging examination showed normal. The patient''s clinical symptoms was improvedafter receiving immunosuppressive treatment.