Periostin 蛋白与成骨相关性的研究进展

Peiostin又称为成骨细胞特异因子2(OSF-2),是一种具有多种功能的细胞外基质蛋白,其在物种形成过程中高度保守,已知其在骨、肿瘤、心血管、呼吸系统以及组织修复中均有作用。研究表明,periostin的表达受多种生长因子和环境因子的调控,通过与整合素受体αvβ3或者Notch 1蛋白的结合,激活FAK和Akt/PKB或者c-Fos等相关信号通路,进而调控多种细胞(成纤维细胞、内皮细胞、上皮细胞、成骨细胞和平滑肌细胞)的分化、粘附、迁移和存活。在既往的研究中,学者们主要探讨了Periostin在肿瘤发生和转移中的作用。尽管其最先发现于骨,但是periostin与骨相关的研究相对较少。近几年,部分研究分析了periostin在骨生物学中的作用,并指出periostin可能参与了骨的形成。本文就已有的periostin在成骨中的研究作一综述。

The Research of the Role of Periostin in Osteogenesis

Peiostin is also known as osteoblast specific factor2 (OSF-2), which is an extracellular matrix protein with multiplefunctions, highly conserved during the process of speciation. It plays an important role in bone, tumor, cardiovascular, respiratory, and intissue repair. Research suggests that the expression of periostin is regulated by a variety of growth factors and environmental factors.Binding with integrin receptor alpha-v-beta3 or Notch 1 protein, periostin can activate FAK, PKB/Akt or c-Fos related signaling pathways, whichregulates the differentiation, adhesion, migration and survival of different cells (fibroblasts, endothelial cells, epithelial cells, osteoblastsand smooth muscle cells). In the past research, scholars have mainly discussed the role of Periostin in tumorigenesis and metastasis.Despite its initial identification in bone, investigations of periostin functions in bone-related physio-pathology are less abundant.Recently, several studies have analyzed the potential role of periostin in bone biology and suggest that periostin may be an importantregulator of bone formation. This paper reviewed the relation between periostin and osteogenesis.