吲哚美辛栓剂对预防ERCP术后高淀粉酶血症及胰腺炎的效果观察

目的:探讨吲哚美辛栓剂对预防ERCP术后高淀粉酶血症及胰腺炎的效果。方法:选取2010年10月-2015年6月收治入院的行ERCP手术的患者300例,随机分为观察组及对照组各150例,观察患者ERCP术后立即应用吲哚美辛栓剂直肠给药,对照组给予安慰剂栓剂,术后3 h,24 h检测血清淀粉酶,观察高淀粉酶血症及胰腺炎的发生情况。结果:术前两组血清淀粉酶比较差异无统计学意义(P0.05);术后3 h,24 h两组血清淀粉酶均升高,且观察组高于对照组,差异均具有统计学意义(t=5.794、10.816,P均0.05)。观察组高淀粉酶血症及ERCP术后胰腺炎的发生率明显低于对照组,差异均具有统计学意义(x~2=5.927;2.160,P0.05)。结论:直肠给药吲哚美辛栓剂可明显降低ERCP术后血清淀粉酶量,降低高淀粉酶血症及ERCP术后胰腺炎的发生率。

Observation of Indomethacin Suppository for the Prevention ofHyperamylasemia and Pancreatitis after ERCP Operation

Objective:To investigate the effect of indomethacin for the prevention of hyperamylasemia and pancreatitis after ERCPoperation.Methods:a total of 300 patients with October 2010 to June 2015 were randomly divided into observation group and controlgroup for each 150 cases. The patients in observation group were given indometacin suppositories by rectal administration, and the patientsin control group were given placebo suppository. The serumamylase was detected, and the incidence hyperamylasemia and pancreatitiswas observed in 3 h, 24 hours after operation.Results:There was no significant difference in the serum amylase before treatmentbetween the two groups (P>0.05); After treatment for 3 h and 24 h, the serum amylase was increased in the two groups, and it was higherin the observation group than that of the control group with statistical significance (t=5.794, 10.816, P<0.05); and the incidence of hyperamylasemiaand pancreatitis after ERCP in the observation group was significantly lower than that of the control group, and the differencewas statistically significant (x2=5.927, 2.160, P<0.05).Conclusion:The rectal indomethacin suppository can significantly decrease theserumamylase level after ERCP and reduce the incidence of hyperamylasemia and PEP.