首页 | 本学科首页   官方微博 | 高级检索  
     

沙格雷酯治疗2型糖尿病伴下肢动脉硬化闭塞症患者的疗效评估
引用本文:康雪冰 燕妮 张颖 沈学然 李元梅. 沙格雷酯治疗2型糖尿病伴下肢动脉硬化闭塞症患者的疗效评估[J]. 现代生物医学进展, 2016, 16(16): 3128-3130
作者姓名:康雪冰 燕妮 张颖 沈学然 李元梅
作者单位:河北省张家口市第二医院内分泌科;2河北省张家口市第二医院药剂科;河北省张家口市第一医院药剂科
摘    要:目的:探讨沙格雷酯治疗2型糖尿病伴下肢动脉硬化闭塞症(ASO)患者的临床疗效。方法:选择2014年4月~2015年5月我院2型糖尿病伴下肢ASO患者80例,给予口服沙格雷酯100 mg,3次/日,连续8周,监测治疗前后患肢的症状与体征、双下肢动脉峰值血流速度、血糖、血脂及血液流变学等指标的变化。结果:口服沙格雷酯8周后,患者疼痛感、冷感、间歇性踱行、麻木感及下肢溃疡等主观症状有效率均大于91%,临床总有效率为93.75%。治疗后患者左、右下肢动脉血管直径与治疗前比较,差异无统计学意义(P0.05),但左、右下肢动脉峰值血流速度比治疗前显著降低,差异有统计学意义(P0.05)。治疗后患者的甘油三酯、总胆固醇、低密度脂蛋白、全血高切黏度及全血低切黏度比治疗前降低,差异有统计学意义(P0.05)。结论:沙格雷酯可改善2型糖尿病伴下肢ASO患者的症状,降低双下肢动脉峰值血流速度,临床疗效确切,值得临床推广应用。

关 键 词:2型糖尿病;下肢动脉硬化闭塞症;沙格雷酯;5- 羟色胺;临床疗效

Type 2 Diabetic Patients with Lower Limb Arteriosclerosis Obliterans:Evaluation of Effect of Sarpogrelate
Abstract:Objective:To study the effect of sarpogrelate in the treatment of type 2 diabetic patients complicated with lower limbarteriosclerosis obliterans (ASO).Methods:A total of 80 patients with type 2 diabetic complicated with lower limb ASO, who weretreated in Zhangjiakou Second Hospital of Hebei Province from April 2014 to May 2015, were selected and given oral sarpogrelate(100mg, 3 times/day) for eight weeks. The changes of symptoms and signs of the limbs, the double lower limbs artery peak flow velocity,blood glucose, blood lipid and blood rheology indexes before and after treatment were detected.Results:After 8 weeks of oralsarpogrelate, the effective rates of subjective symptom of pain, cold feeling, intermittent strolled, numbness and lower limb ulcer weremore than 91%, and the clinical total effective rate was 93.75%. There were no significance in the left and right lower limb arterydiameter compared with before treatment (P>0.05), but the left and right lower limb artery peak flow was reduced compared with beforetreatment, the difference was statistically significant (P<0.05). The levels of triglyceride, total cholesterol, low density lipoprotein, wholeblood high shear viscosity and whole blood low shear viscosity were lower than before treatment, the difference was statisticallysignificant (P<0.05).Conclusion:Sarpogrelate can improve the symptoms of type 2 diabetes patients with lower limb arteriosclerosisobliterans and reduce the lower limb artery blood flow velocity, with a definite clinical effect, which is worthy of clinical application.
Keywords:Type 2 diabetes   Lower limb arteriosclerosis obliterans   Sarpogrelate   5-HT   Clinical efficacy
本文献已被 CNKI 等数据库收录!
点击此处可从《现代生物医学进展》浏览原始摘要信息
点击此处可从《现代生物医学进展》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号