脑出血患者脑脊液Abeta水平检测及其临床意义

目的:探讨脑出血患者脑脊液中amylid-beta(Aβ)40和Aβ42水平及其与出血量以及血肿周围低密体积相关性。方法:采集73例脑出血患者及72例健康对照的脑脊液标本,采用酶联免疫吸附法(Elisa)检测脑脊液中的Aβ40和Aβ42的水平,分析其与出血量和血肿周围低密度体积的相关性。结果:(1)脑出血患者脑脊液Aβ40和Aβ42水平显著高于健康对照组(P0.01)。(2)脑出血患者脑脊液Aβ40(r=0.549,P0.01;r=0.791,P0.01)和Aβ42(r=0.450,P0.01;r=0.440,P0.01)水平与出血量及血肿周围低密度体积呈正相关。结论:Aβ40和Aβ42水平为神经元损害的标志物,本研究提示脑脊液Aβ40和Aβ42水平对于判断脑出血严重程度具有临床参考价值。

Abeta Levels in the CSF of Patients with Intracerebral Hemorrhage

Objective:To investigate the levels of Abeta40 and Abeta42 in the CSF of patents with intracerebral hemorrhage(ICH) and their correlations with the hemorrhagic volume and the volume of perihematomal hypodensity.Methods:Enzyme-linkedimmuno sorbent assay (Elisa) was used to investigate the levels of Abeta40 and Abeta42 in CSF of 73 ICH patients and 72 normalcontrols (NC).Results:The levels of Abeta40 and Abeta42 in CSF were significantly increased in ICH patients when compared with NCgroup (P<0.01). The levels of Abeta40 in CSF (r=0.549, P<0.01; r=0.791, P<0.01) and Abeta42 (r=0.450, P<0.01; r=0.440, P<0.01) werepositively correlated with the hemorrhagic volume and the volume of perihematomal hypodensity.Conclusion:As the levels of Abetaproteins in CSF reflect the status of neuronal degeneration, the increased levels of Abeta in CSF indicate that ICH patients experiencesignificant neuronal degeneration. In this regard, the Abeta levels in CSF might be valuable for estimation of the disease severity of ICHpatients.