口服咪达唑仑对儿童术前分离焦虑的效果分析

目的:明确与父母分离焦虑在不同年龄段小儿的发生率,并探讨术前口服咪达唑仑对减轻患儿术前焦虑的效果。方法:募集442例年龄12岁的非心脏手术患儿,分为咪达唑仑组和对照组,每组再按照年龄分为五个年龄段。咪达唑仑组患儿术前30分钟给予0.5 mg/kg咪达唑仑口服;对照组则未予任何制剂。观察并比较不同年龄段患儿入手术室与家长分离时的情况。结果:药物组分离焦虑发生率显著低于对照组。在各年龄组中,8个月到3岁的婴幼儿是发生分离焦虑比例最高的年龄段。对照组分离焦虑的发生率为16.94%,研究组为8%,较对照组有显著下降(P0.05)。此外,研究组小于8个月和3-5岁组患儿发生分离焦虑的比例也均较未用药组有显著下降(P0.05)。结论:分离焦虑与患儿年龄相关,低龄患儿在手术前有明显的分离焦虑,术前30分钟口服咪达唑仑0.5 mg/kg能显著改善分离时的焦虑,但不能完全消除。

The Effect Analysis of Oral MidazolamDecreasing Dissociative Anxiety in Surgical Children

Objective:Our aim of this study is to investigate the incidence of dissociative anxiety in children and to analyse theeffect of oral midazolamin facilitating separation fromparents.Methods:A total of 442 children (aged <12 years) undergoing noncardiacsurgery were involved in the study. They were divided into two groups, Midazolam Group (Mgroup) and Control group (C group). Ineach group, children were divided into 5 categories according to the age. Oral midazolam 0.5mg/kg was given to the children inMgroup30 minutes before anesthesia. Children in C group were given nothing. To observe and compare the behavioral manifestation when thechildren were separated from their parents.Results:The infants aged from 8 months to 3 years have most difficulties in separation fromparents in all age categories. In all the children, dissociative anxiety occurs in 16.94%children ofC group and 8%ofMgroup. Moreover,the incidence of dissociative anxiety is significantly decreasing among the children aged <8 months and aged from 3 to 5 years in Mgroup (P < 0.05).Conclusion:Dissociative anxiety is very common in older infants and younger children undergoing surgery. Theincidents is significantly related with age. Oral midazolam0.5 mg/kg 30 minutes before separation is effective on decreasing dissociativeanxiety, but never eliminating it.