不同化疗方案联合手术治疗非小细胞肺癌的临床疗效及对患者免疫功能的影响分析

目的:探讨分析不同化疗方案联合手术治疗非小细胞肺癌的临床疗效以及对患者免疫功能的影响。方法:经病理学证实的非小细胞肺癌患者94例,随机数字表法将其分为顺铂组与洛铂组,各47例。2组患者均采取手术治疗,并术前行辅助化疗。其中顺铂组采取紫杉醇+顺铂方案,洛铂组接受紫杉醇+洛铂方案。比较治疗前后2组患者临床疗效及KPS评分,并对Ig A、Ig G、Ig M、CD4+及CD8+指标水平进行分析。结果:洛铂组有效率(CR+PR)为87.2%(41/47),与顺铂组[80.8%(38/47)]差异无统计学意义(P0.05)。洛铂组术后KPS评分及CD4+水平高于顺铂组(P0.05),但CD8+水平低于顺铂组(P0.05),差异有统计学意义;2组患者手术前后Ig A、Ig G及Ig M均无统计学意义(P0.05)。洛铂组毒副反应发生率低于顺铂组(P0.05)。结论:含洛铂术前辅助化疗方案有助于改善非小细胞肺癌患者的免疫功能,降低化疗的毒副反应。

Analysis of Clinical Efficacy and Effect on the Immune Function of DifferentChemotherapy which combined with Surgery in the Treatment of Non SmallCell Lung Cancer Patients

Objective:To investigate the clinical efficacy and immune function of different chemotherapy combined with surgeryin the treatment of patients with non-small cell lung cancer.Methods:94 cases of non-small cell lung cancer confirmed by pathologywere randomly divided into cisplatin group and lobaplatin group respectively, each of 47 cases. They all treated with surgery andconducted to the supporting chemotherapy in the former. The cisplatin group received paclitaxel and cisplatin, while the lobaplatin groupreceived paclitaxel and lobaplatin. The total effective rate, KPS score, IgA, IgG, IgM, CD4+ and CD8+ between both groups werecompared.Results:The total effective rate was 87.2%(41/47) in the lobaplatin group and 80.8%(38/47) in the cisplatin grouprespectively, there was no significant difference between both groups (P>0.05). The KPS score and CD4+ level of the lobaplatin groupwere higher than that of the cisplatin group (P<0.05), but the level of CD8+ was lower than that of the cisplatin group (P<0.05). Thelevel of IgG, IgM and IgA were no statistical significant difference in 2 groups (P>0.05). The incidence of adverse reaction in thelobaplatin group was lower than that of the cisplatin group (P<0.05).Conclusion:Preoperative adjuvant chemotherapy with platinumcontaining chemotherapy can improve the immune function in patients with non small cell lung cancer, and reduce the side effects ofchemotherapy.