缬沙坦联合氨氯地平治疗高血压伴左心肥厚的疗效及对心功能的影响

目的:通过探讨缬沙坦联合氨氯地平治疗高血压伴左心肥厚患者的疗效及对心功能的影响,为临床治疗提供依据。方法:选择2010年1月~2014年12月我院收治的高血压伴左心室肥厚患者共120例,按照随机数字表法随机分为观察组和对照组。对照组患者给予氨氯地平,观察组患者缬沙坦联合氨氯地平治疗,治疗6个月后,观察两组患者舒张压(DBP)、收缩压(SBP)、心率(HR)、室间隔厚度(IVST),左室后壁厚度(LVPWT)、左室舒张末期内径(LVDd)和左室重量指数(LVMI)。结果:治疗后,两组患者SBP、DBP和HR均较治疗前显著降低,差异有统计学意义(P0.05);观察组患者SBP、DBP和HR均低于对照组,差异有统计学意义(P0.05)。治疗后,两组患者IVST、IVPWT、LVDd和LVMI均较治疗前显著降低,差异有统计学意义(P0.05);观察组患者IVST、IVPWT、LVDd和LVMI均低于对照组,差异有统计学意义(P0.05)。结论:缬沙坦联合氨氯地平治疗高血压伴左心肥厚患者,能够降低患者血压、逆转左心室肥厚,改善患者心功能,疗效优于氨氯地平单独治疗,值得临床推广应用。

Valsartan plus Amlodipine for Hypertension Complicated by Left VentricularHypertrophy: Its Clinical Efficacy and Influence on Heart Function

Objective:To explore the clinical efficacy and the influence on heart function of valsartan plus amlodipine in the treatmentof hypertension complicated by left ventricular hypertrophy,and to provide the reference for clinical therapy.Methods:A total of120 patients with hypertension complicated by left ventricular hypertrophy, who were admitted to Second Affiliated Hospital of Xi''anJiao Tong University from January 2010 to December 2014, were selected and randomly divided into observation group and controlgroup. The control group was treated with amlodipine, while the observation group was treated with valsartan plus amlodipine. After 6months of treatment, the diastolic blood pressure(DBP), systolic blood pressure(SBP), heart rate (HR), interventricular septal thickness(IVST), left ventricular posterior wall thickness(LVPWT), left ventricular end diastolic diameter(LVDd), and left ventricular mass index(LVMI) in the two groups were observed.Results:Compared with before treatment, SBP, DBP, and HR in the two groups after treatmentwere significantly reduced, the differences were statistically significant (P<0.05); and the above indexes in the observation group werelower than those in the control group, the differences were statistically significant (P<0.05); IVST, IVPWT, LVDd and LVMI in the twogroups after treatment were significantly reduced, the differences were statistically significant (P<0.05), and the above indexes in the observationgroup were lower than those in the control group, the differences were statistically significant (P<0.05).Conclusion:Valsartanplus amlodipine can significantly cut down the blood pressure, reverse left ventricular hypertrophy and improve the heart function in thetreatment of patients with hypertension complicated by left ventricular hypertrophy, its clinical efficacy is better than amlodipine alone,which is worthy of clinical popularization and application.