5%环孢菌素霜对银屑病合并代谢综合征患者血清IL-17 及IL-18 水平的影响

目的:探讨5%环孢菌素霜对银屑病合并代谢综合征患者外周血IL-17、IL-18水平及PASI评分的影响。方法:选择我院收治的寻常型银屑病合并代谢综合症患者68例,分为实验组和对照组。对照组予以复方甘草酸苷和卡泊三醇治疗,实验组在此基础上加用制备好的5%环孢菌素霜,观察并比较两组患者治疗前后外周血IL-17及IL-18水平的变化情况以及血压、空腹血糖、血脂及PASI评分结果。结果:与治疗前比较,两组患者治疗后IL-17及IL-18水平、血压、FPG、TG及PASI评分均显著降低,而HDL-C明显升高,差异均具有统计学意义(P0.05);与对照组比较,实验组治疗后IL-17及IL-18水平、血压、FPG、TG及PASI评分较低,而HDL-C较高,差异均具有统计学意义(P0.05)。结论:5%环孢菌素霜辅助治疗可调节银屑病合并代谢综合征患者外周血IL-17、IL-18水平,降低其PASI评分,改善患者机体代谢紊乱状态,对银屑病合并代谢综合症有显著临床疗效。

Effects of 5%Cyclosporin on the Levels of IL-18 and IL-17 in SerumofPatients with Psoriasis and Metabolic Syndrome

Objective:To investigate the effect of 5%cyclosporin cream on the changes of IL-18, IL-17 levels in peripheral bloodand PASI of psoriasis patients combined with metabolic syndrome.Methods:68 cases of psoriasis patients with metabolic syndrome whowere treated in our hospital were selected and randomly divided into the control group and the experimental group. The patients in controlgroup were treated with the compound licorice injection, while the patients in experimental group were treated with the 5% cyclosporinon the basis of control group. Then the levels of IL-17 and IL-18 in serum, blood pressure, FPG, TG and the PASI scores inboth groups were observed and compared before and after the treatment.Results:Compared with before treatment, the levels of IL-17and IL-18 in serum, blood pressure, FPG, TG and the PASI scores decreased in both groups after the treatment (P<0.05). Compared withthe control group, the levels of IL-17 and IL-18 in serum, blood pressure, FPG, TG and the PASI score were lower in the experimentalgroup after the treatment (P<0.05).Conclusion:5%cyclosporin creamcould regulate the levels of IL-18 and IL-17 in peripheral blood ofpatients with psoriasis combined with metabolic syndrome, reduce the PASI score and improve the metabolic disorder.