环孢霉素A治疗儿童再生障碍性贫血的临床疗效研究

目的:探讨环孢霉素A治疗儿童再生障碍性贫血患者的临床疗效。方法:选择在我院就诊或住院治疗的50例儿童再生障碍性贫血患者,随机分为实验组和对照组,每组25例。对照组患者给予司坦唑醇治疗,实验组患者在对照组基础上给予环孢素治疗。治疗结束后,检测并比较两组患者的血清雌二醇、睾酮水平、网织红细胞计数以及临床疗效。结果:与治疗前相比,两组患者治疗后的血清雌二醇水平均显著下降(P0.05),血清睾酮水平以及网织红细胞计数水平均明显升高(P0.05);与对照组相比,实验组患者的血清雌二醇水平较低(P0.05),血清睾酮水平以及网织红细胞计数水平较高(P0.05)。此外,实验组的临床治疗总有效率较对照组明显升高(P0.05)。结论:环孢霉素A可提高儿童AA患者的疗效,可能与其降低血清雌二醇水平,升高血清睾酮水平以及网织红细胞计数水平有关。

Clinical Effect of Cyclosporin A on Children with Aplastic Anemia

Objective:To investigate the clinical effect of cyclosporinA in the treatment of children with aplastic anemia.Methods:50 children with aplastic anemia in our hospital were randomly divided into the experimental group and control group, 25 cases in each group. The control group was treated with stanozolol, patients in the experimental group were given cyclosporine treatment based on the control group. At the end of treatment, the levels of serum estradiol, testosterone, and the clinical efficacy of both groups were detected and compared.Results:Compared with before treatment, the serumestradiol levels of both groups were significantly decreased (P<0.05), the serumtestosterone level and net woven red blood cell count level were significantly increased(P<0.05) after treatment, compared with the control group, the serum estradiol level of experimental group was lower (P<0.05), the serum testosterone level and network fabric red cell count were higher(P<0.05). In addition, the total effective rate of experimental group was significantly higher than that of the control group (P<0.05).Conclusion:Cyclosporin A could improve the efficacy of AA in children, which might be related to the decrease of serumestradiol level, the increase of serumtestosterone level and red blood cell count.