动脉粥样硬化脂代谢紊乱与DNA甲基化的关系

心血管疾病是导致人类死亡的主要原因之一,动脉粥样硬化(Atherosclerosis,As)是心血管疾病的重要病理基础,炎症反应是动脉粥样硬化的重要病理机制。脂代谢紊乱是动脉粥样硬化的独立危险因素,贯穿动脉粥样硬化的始终,并且是导致炎症反应发生的重要原因。DNA甲基化是一种不改变基因核苷酸序列而能调控基因表达的一种重要的表观遗传学方式。有研究证明,脂代谢紊乱的发生、发展与DNA甲基化存在密切关系。本文将围绕与脂代谢紊乱相关基因对动脉粥样硬化过程中脂代谢紊乱与DNA甲基化的关系做一综述。

Relationship between the Dyslipidemia and DNA Methylation in Atherosclerosis

The cardiovascular disease is one of the main causes of the humans death, and atherosclerosis, of which the inflammation reaction being an important pathological mechanism, is the pathological basis of it. Dyslipidemia, an important cause of inflammatory reaction, is an independent risk factor for atherosclerosis, occupying the whole progress. DNA methylation is one important way of epigenetics without changing the sequences of nucleotide and can regulate the genes expressions. Studies had shown, that the occurrence and development of dyslipidemia have close relationship with DNA methylation. The relationship between dyslipidemia and DNA methylation in the atherosclerosis fromthe dyslipidemia-related genes was reviewed in this article.