小檗碱抗氧化和抗炎作用用于糖尿病治疗的机制研究进展

研究表明氧化应激反应和慢性炎症反应是2型糖尿病糖、脂代谢紊乱和胰岛素抵抗发生的重要病理机制。小檗碱是中药黄连的主要有效成分之一。体内、外研究证实小檗碱可通过抗氧化和抗炎作用发挥对2型糖尿病的治疗作用。本文就小檗碱抗氧化和抗炎作用用于2型糖尿病治疗的分子机制研究进展作一综述。小檗碱抗氧化和抗炎作用机制复杂,目前的研究显示小檗碱可通过AMPK通路、MAPK通路、Nrf2通路和NF-κB通路发挥抗氧化和抗炎作用。然而,小檗碱的抗氧化和抗炎作用仍需进一步的深入研究证实。明确小檗碱的抗氧化和抗炎作用的分子机制,有助于进一步了解小檗碱治疗糖尿病作用的机理,为探寻治疗糖尿病的天然药物提供理论依据。

Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus

Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Recent studies showed that Berberine had antioxidant and anti-inflammatory activities, which contributed in part to its efficacy against diabetes mellitus. In this review, we summarized the antioxidant and anti-inflammatory activities of BBR as well as their molecular basis. The antioxidant and anti-inflammatory activities of berberine were mediated through multiple cellular kinases and signaling pathways, such as AMP activated protein kinase(AMPK), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid-2-related factor-2 (Nrf2) pathway, and nuclear factor-kB (NF-kB) pathway. However, detailed mechanisms and pathways of berberine still need further investigation. Clarification of these issues could help to understand the pharmacology of berberine in the treatment of diabetes mellitus and promote the development of antidiabetic natural products.