唑尼沙胺单药治疗儿童癫痫疗效及骨代谢的影响

目的:探讨唑尼沙胺(Zonisamide ZNS)对儿童癫痫疗效及骨代谢的影响。方法:选择2013年3月至2014年3月到河北省儿童医院神经内科门诊及病房就诊的新诊断癫痫患儿,其中男性36名,女性24名,年龄在2-14岁,给予唑尼沙胺单药治疗,分别于服药前、服药后6月查血甲状旁腺素、血钙、磷、碱性磷酸酶和骨密度测定,并与对照组进行对比。对照组选择就诊于儿保科年龄、性别相匹配的正常儿童。并分析癫痫患儿发作频率及严重程度,评估疗效。结果:唑尼沙胺治疗53例癫痫患儿中,42例(79.2)无发作,8例(15%)有效,3例(5.7%)无效。且对骨代谢相关血清学指标、骨密度无明显影响。结论:ZNS对儿童癫痫有显著疗效,是一种广谱、耐受良好的抗癫痫药。

Clinical Efficacy of Zonisamide Monotherapy and Its Effect on BoneMetabolismof Epilepsy Children

Objective:To study the influence of zonisamide (ZNS) on the curative effect of epileptic children and their bonemetabolism.Methods:The newly diagnosed epilepsy patients in our hospital were selected in this study, including 36 male and 24 female,aged from 2 to 14 years old. They were given zonisamide monotherapy. And their blood parathyroid hormone, calcium, phosphorus,alkaline phosphatase and bone mineral density were detected respectively before taking the medicine, at 6 months after taking thismedicine. Data were compared with that of the control group. The age and gender matched normal children fromour children''s health departmentwere selected as control group. Analyze the epilepsy seizure frequency and severity of children and evaluate the curative effect.Results:Among the 53 epilepsy children treated with zonisamide, 42 cases (79.2%) had no attack, and 8 cases (15%) got curative effect.Zonisamide was invalid for 3 patients (5.7%). It had no obvious effect on the bone metabolismrelated serological indexes and bone mineraldensity.Conclusion:ZNS have remarkable curative effect on children epilepsy. Therefore, it is a kind of broad-spectrum antiepilepticdrugs and can be well tolerated.