Single channel and monolayer studies of acylated gramicidin A: influence of the length of the alkyl group |
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Authors: | A. Benayad D. Benamar N. Van Mau G. Page F. Heitz |
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Affiliation: | (1) Laboratoire de Physicochimie des Systèmes Polyphasés, URA 330, CNRS, Route de Mende, B. P. 5051, France;(2) G. d. R. Canaux Peptidiques Transmembranaires Structures et Activités , F-34033 Montpellier Cedex, France;(3) G. D. P. C. Université de Montpellier II, F-34095 Montpellier, France |
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Abstract: | Three different gramicidin A analogues bearing acyl chains of various length on the ethanolamine moiety have been studied by investigating their single channel behaviour and their monolayer properties. It is shown that the single channel conductance does not depend on the substitution of the ethanolamine OH group and that the channel lifetime is roughly proportional to the length of the alkyl chain. The monolayer study indicates that acylation of gramicidin A produces compounds which have medium-dependent conformations. These acylated compounds are miscible with lipids, while GA is not, and the surface potential is not modified by the esterification of the alcohol group.Offprint requests to: F. Heitz |
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Keywords: | Gramicidin A analogues Monolayers Lipid-peptide interactions |
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