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Structural analysis of the mouse T-cell receptor Tcra V2 subfamily |
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| Authors: | Kai Wang Chia-Lam Kou Kuang-Chuan Cheng Mi-Kyung Lee Bryan Paeper Ben F Koop Tai-June Yoo Leroy Hood |
| Institution: | (1) Division of Biology 147-75, California Institute of Technology, 91125 Pasadena, CA, USA;(2) Present address: Department of Molecular Biotechnology GJ-10, University of Washington, 98195 Seattle, WA, USA;(3) Present address: Institute of Biomedical Sciences, national Taiwan University, P. O. Box 23-106, Taipei, Taiwan, Republic of China;(4) Present address: Division of Allergy and Immunology, University of Tennessee, 38163 Memphis, TN, USA;(5) Present address: Center for Environmental Health, Department of Biology, University of Victoria, V8W 2Y2 Victoria, BC, Canada |
| Abstract: | Cosmid clones containing T-cell receptor Tcra V2 subfamily gene segments have been isolated from a BALB/c cosmid library and subjected to DNA sequence analysis. The V gene segments in the Tcra V2 subfamily differ from each other by 3%–7% at the nucleotide level and 5%–16% at the amino acid level. T-cell receptor Tcra V2 gene segment polymorphisms have been identified in the B10.PL and PL/J mouse strains with a Tcra V2 subfamily-specific probe. These V gene segment polymorphisms may cause the differential Tcra V gene usage in induced experimental allergic encephalomyelitis between B10.PL and PL/J mice.The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide database and have been assigned the accession numbers U04312 and U04622-U04626 |
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