| Abstract: | A fluorescent probe was used to study hydrocortisone (10 microM) action on mitogen-stimulated free cytoplasmic calcium level in lymphocytes of patients with bronchial asthma. The patients were divided into two groups according to their sensitivity to glucocorticoid therapy. Hydrocortisone-specific calcium-blocking effect was absent in hormone-resistant patients. Lymphocytes of hormone-sensitive patients responded to hydrocortisone administration by a decline of mitogen-induced calcium level. |
