Hominoid chromosomal rearrangements on 17q map to complex regions of segmental duplication |
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| Authors: | Maria Francesca Cardone Zhaoshi Jiang Pietro D'Addabbo Nicoletta Archidiacono Mariano Rocchi Evan E Eichler Mario Ventura |
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| Institution: | (1) Department of Genetics and Microbiology, University of Bari, Via Amendola, Bari, 70126, Italy;(2) Department of Genome Sciences, University of Washington School of Medicine and the Howard Hughes Medical Institute, NE Pacific Street, Seattle, Washington 98195, USA;(3) Howard Hughes Medical Institute, NE Pacific Street, Seattle, Washington 98195, USA |
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| Abstract: | Background Chromosomal rearrangements, such as translocations and inversions, are recurrent phenomena during evolution, and both of them
are involved in reproductive isolation and speciation. To better understand the molecular basis of chromosome rearrangements
and their part in karyotype evolution, we have investigated the history of human chromosome 17 by comparative fluorescence
in situ hybridization (FISH) and sequence analysis. |
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