Glomerular binding of angiotensin II in the rainbow trout,Salmo gairdneri |
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Authors: | J Anne Brown Susan M Taylor Christopher J Gray |
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Institution: | (1) Department of Biological Sciences, University of Exeter, EX4 4PS Exeter, United Kingdom;(2) Department of Zoology, University of Hull, Hull, United Kingdom |
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Abstract: | Summary Isolated glomeruli of the rainbow trout have been exposed in vitro to125I-angiotensin II (0.88 × 10–9 M) and binding sites located by light-microscopic autoradiography. These studies provide evidence of specific binding of angiotensin II by glomeruli. Binding was significantly inhibited by excess (10–5 M) unlabelled angiotensin II, but a high degree of non-specific binding also occurred. The mammalian competitive antagonist, saralasin (3 × 10–7 M) did not influence125I-angiotensin II binding to fish glomeruli. Intense binding of125I-angiotensin II was noted at the vascular pole of some glomeruli. |
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Keywords: | Kidney Glomerulus Angiotensin II Salmo gairdneri (Teleostei) |
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